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Combating Illicit Xylazine Act

4/21/2026, 5:24 PM

Summary of Bill S 545

Bill 119 s 545, also known as the "Xylazine Prohibition Act," aims to restrict the use of xylazine for certain purposes. Xylazine is a sedative commonly used in veterinary medicine, but it has also been misused as a recreational drug, particularly in combination with opioids.

The bill prohibits the use of xylazine for non-medical purposes, such as recreational drug use or as an adulterant in illicit substances. It also imposes penalties for those found in violation of the prohibition, including fines and potential imprisonment.

The legislation is intended to address the growing concern over the misuse of xylazine and its potential dangers to public health. Supporters of the bill argue that restricting access to xylazine for non-medical purposes will help prevent overdoses and other negative health outcomes associated with its misuse. Opponents of the bill may argue that it could limit access to xylazine for legitimate medical purposes, potentially impacting veterinary care. However, the bill includes provisions to ensure that xylazine remains available for veterinary use under appropriate circumstances. Overall, Bill 119 s 545 seeks to strike a balance between addressing the misuse of xylazine and ensuring that it remains available for necessary medical purposes. It reflects a growing recognition of the need to address the misuse of certain substances and protect public health.

Congressional Summary of S 545

Combating Illicit Xylazine Act

This bill regulates xylazine under the Controlled Substances Act (CSA).

Xylazine, also known as tranq, is a nonopioid sedative and pain reliever that is approved for use in animals. Recently, the Drug Enforcement Administration (DEA) has reported an increase in trafficking of fentanyl mixed with xylazine.

This bill adds xylazine, including its salts, isomers, and salts of isomers, to schedule III of the CSA. Schedule III controlled substances, including anabolic steroids, buprenorphine, and ketamine, have less potential for abuse than a schedule I or II substance, have a currently accepted medical use, and have low or moderate risk of dependence if abused.

Under the bill, manufacturing, distributing, or dispensing xylazine, or possessing with intent to manufacture, distribute, or dispense xylazine for illicit use is subject to criminal penalties under the CSA. The bill also requires xylazine transactions to be tracked in the drug reporting system maintained by the DEA.

The bill exempts from registration under the CSA persons and entities that possess xylazine (1) lawfully dispensed by a veterinarian or pharmacy and (2) for an animal or for use in certain animal-control or wildlife programs.

The bill also exempts xylazine manufacturers from the CSA's physical security requirements.

Finally, the bill requires the DEA, in coordination with the Department of Health and Human Services (HHS), to provide Congress with a report on how the agencies previously determined whether xylazine should be a controlled substance, including the full text of HHS's recommendations to the DEA for scheduling xylazine.

Current Status of Bill S 545

Bill S 545 is currently in the status of Bill Introduced since February 12, 2025. Bill S 545 was introduced during Congress 119 and was introduced to the Senate on February 12, 2025.  Bill S 545's most recent activity was Placed on Senate Legislative Calendar under General Orders. Calendar No. 372. as of April 15, 2026

Bipartisan Support of Bill S 545

Total Number of Sponsors
1
Democrat Sponsors
1
Republican Sponsors
0
Unaffiliated Sponsors
0
Total Number of Cosponsors
91
Democrat Cosponsors
46
Republican Cosponsors
44
Unaffiliated Cosponsors
1

Policy Area and Potential Impact of Bill S 545

Primary Policy Focus

Crime and Law Enforcement

Alternate Title(s) of Bill S 545

A bill to prohibit certain uses of xylazine, and for other purposes.
A bill to prohibit certain uses of xylazine, and for other purposes.

Comments

David Schwartz profile image

David Schwartz

980

3 months ago

This bill bad for me. It make things worse. I no like it.

Yahir Upchurch profile image

Yahir Upchurch

874

1 year ago

I think this bill is great! It's gonna make things better for everyone. Can't wait to see how it all turns out!

Makai Moon profile image

Makai Moon

968

1 year ago

So, like, what's the deal with this bill trying to ban xylazine? I mean, I use that stuff for my horses all the time, and now they wanna take it away? How am I supposed to take care of my animals without it? This is seriously messed up. Can someone explain why they're trying to do this? #confused #notcool