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Department of Health and Human Services Awarded a Contract to SPERO THERAPEUTICS, INC. for $49,795,199.00

Signed on

7/12/2018, 12:00 AM

SPERO THERAPEUTICS, INC. Government Contract #75A50118C00015

SPERO THERAPEUTICS, INC. was awarded a contract with the United States Government for $49,795,199.00. The contract was awarded by the agency office BARDA - ASPR / DAAPPO / BARDA DCMA, which is a division with the Office of Assistant Secretary for Preparedness and Response within the Department of Health and Human Services.

Summary of Award

SPERO THERAPEUTICS, INC., a U.S.-Owned Business based in Massachusetts, received a federal contract worth $49,795,199 from the Department of Health and Human Services. The contract is for developing SPR994, an oral carbapenem for treating drug-resistant Gram-negative bacterial infections. Notable transactions include a payment of $11,697,110 and $12,498,467, with various other transactions involving modifications to the contract.

Contract Details

Contract ID75A50118C00015
Contract TypeD
Total Obligation$49,795,199.00
Exercised Options$49,795,199.00
Base Amount + Options$49,795,199.00
Date Signed2018-07-12
Contract DescriptionIGF::OT::IGF
Start Date2018-07-12
End Date2026-10-31

Agency Details

Awarding AgencyDepartment of Health and Human Services
Awarding Sub AgencyOffice of Assistant Secretary for Preparedness and Response
Awarding OfficeBARDA - ASPR / DAAPPO / BARDA DCMA
Funding AgencyDepartment of Health and Human Services
Funding Sub AgencyOffice of Assistant Secretary for Preparedness and Response
Funding OfficeBARDA - ASPR / DAAPPO / BARDA DCMA

Recipient Details

RecipientSPERO THERAPEUTICS, INC.
Recipient Location675 MASSACHUSETTS AVE 14TH FLR CAMBRIDGE MASSACHUSETTS, UNITED STATES
Business CategoriesCategory Business, Corporate Entity Not Tax Exempt, Self-Certified Small Disadvantaged Business, Small Business, Special Designations, U.S.-Owned Business

Comments

Award Transactions

Transaction #P00019$6,422,390.00June 17, 2025

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $6,422,390.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00018$0.00December 23, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00017$0.00November 20, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00016$0.00July 23, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00015$11,697,110.00July 3, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $11,697,110.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00014$641,630.00December 20, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $641,630.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00013$0.00October 20, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00012$0.00July 11, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00011$0.00January 10, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00010$0.00October 25, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00009$12,498,467.00September 28, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $12,498,467.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00008$-12,498,467.00September 21, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $-12,498,467.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00007$0.00February 11, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00006$12,900,000.00January 14, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $12,900,000.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00005$0.00October 27, 2021

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00004$0.00May 27, 2021

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00003$0.00November 3, 2020

Immediate Office of the Secretary, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00002$0.00January 31, 2020

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00001$2,476,034.00May 19, 2019

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $2,476,034.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #0$15,658,035.00July 12, 2018

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $15,658,035.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00021$-61,887.86September 4, 2025

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $-61,887.86 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00020$0.00July 14, 2025

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00019$6,422,390.00June 17, 2025

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $6,422,390.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00018$0.00December 23, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00017$0.00November 20, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00016$0.00July 23, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00015$11,697,110.00July 3, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $11,697,110.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00014$641,630.00December 20, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $641,630.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00013$0.00October 20, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00012$0.00July 11, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00011$0.00January 10, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00010$0.00October 25, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00009$12,498,467.00September 28, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $12,498,467.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00008$-12,498,467.00September 21, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $-12,498,467.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00007$0.00February 11, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00006$12,900,000.00January 14, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $12,900,000.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00005$0.00October 27, 2021

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00004$0.00May 27, 2021

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00003$0.00November 3, 2020

Immediate Office of the Secretary, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00002$0.00January 31, 2020

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00001$2,476,034.00May 19, 2019

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $2,476,034.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #0$15,658,035.00July 12, 2018

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $15,658,035.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

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