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Department of Health and Human Services Awarded a Contract to SPERO THERAPEUTICS, INC. for $49,795,199.00

Signed on

7/12/2018, 12:00 AM

SPERO THERAPEUTICS, INC. Government Contract #75A50118C00015

SPERO THERAPEUTICS, INC. was awarded a contract with the United States Government for $49,795,199.00. The contract was awarded by the agency office BARDA - ASPR / DAAPPO / BARDA DCMA, which is a division with the Office of Assistant Secretary for Preparedness and Response within the Department of Health and Human Services.

Summary of Award

SPERO THERAPEUTICS, INC., a U.S.-Owned Business based in Massachusetts, received a federal contract worth $49,795,199 from the Department of Health and Human Services. The contract is for developing SPR994, an oral carbapenem for treating drug-resistant Gram-negative bacterial infections. Notable transactions include a payment of $11,697,110 and $12,498,467, with various other transactions involving modifications to the contract.

Contract Details

Contract ID75A50118C00015
Contract TypeD
Total Obligation$49,795,199.00
Exercised Options$49,795,199.00
Base Amount + Options$49,795,199.00
Date Signed2018-07-12
Contract DescriptionIGF::OT::IGF
Start Date2018-07-12
End Date2026-10-31

Agency Details

Awarding AgencyDepartment of Health and Human Services
Awarding Sub AgencyOffice of Assistant Secretary for Preparedness and Response
Awarding OfficeBARDA - ASPR / DAAPPO / BARDA DCMA
Funding AgencyDepartment of Health and Human Services
Funding Sub AgencyOffice of Assistant Secretary for Preparedness and Response
Funding OfficeBARDA - ASPR / DAAPPO / BARDA DCMA

Recipient Details

RecipientSPERO THERAPEUTICS, INC.
Recipient Location675 MASSACHUSETTS AVE 14TH FLR CAMBRIDGE MASSACHUSETTS, UNITED STATES
Business CategoriesCategory Business, Corporate Entity Not Tax Exempt, Self-Certified Small Disadvantaged Business, Small Business, Special Designations, U.S.-Owned Business

Comments

Award Transactions

Transaction #P00019 | $6,422,390.00June 17, 2025

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $6,422,390.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00018 | $0.00December 23, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00017 | $0.00November 20, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00016 | $0.00July 23, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00015 | $11,697,110.00July 3, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $11,697,110.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00014 | $641,630.00December 20, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $641,630.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00013 | $0.00October 20, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00012 | $0.00July 11, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00011 | $0.00January 10, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00010 | $0.00October 25, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00009 | $12,498,467.00September 28, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $12,498,467.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00008 | $-12,498,467.00September 21, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $-12,498,467.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00007 | $0.00February 11, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00006 | $12,900,000.00January 14, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $12,900,000.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00005 | $0.00October 27, 2021

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00004 | $0.00May 27, 2021

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00003 | $0.00November 3, 2020

Immediate Office of the Secretary, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00002 | $0.00January 31, 2020

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00001 | $2,476,034.00May 19, 2019

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $2,476,034.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #0 | $15,658,035.00July 12, 2018

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $15,658,035.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00021 | $-61,887.86September 4, 2025

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $-61,887.86 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00020 | $0.00July 14, 2025

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00019 | $6,422,390.00June 17, 2025

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $6,422,390.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00018 | $0.00December 23, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00017 | $0.00November 20, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00016 | $0.00July 23, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00015 | $11,697,110.00July 3, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $11,697,110.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00014 | $641,630.00December 20, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $641,630.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00013 | $0.00October 20, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00012 | $0.00July 11, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00011 | $0.00January 10, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00010 | $0.00October 25, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00009 | $12,498,467.00September 28, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $12,498,467.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00008 | $-12,498,467.00September 21, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $-12,498,467.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00007 | $0.00February 11, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00006 | $12,900,000.00January 14, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $12,900,000.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00005 | $0.00October 27, 2021

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00004 | $0.00May 27, 2021

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00003 | $0.00November 3, 2020

Immediate Office of the Secretary, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00002 | $0.00January 31, 2020

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00001 | $2,476,034.00May 19, 2019

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $2,476,034.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #0 | $15,658,035.00July 12, 2018

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $15,658,035.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00022 | $-537,177.64July 6, 2026

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $-537,177.64 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00021 | $-61,887.86September 4, 2025

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $-61,887.86 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00020 | $0.00July 14, 2025

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00019 | $6,422,390.00June 17, 2025

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $6,422,390.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00018 | $0.00December 23, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00017 | $0.00November 20, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00016 | $0.00July 23, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00015 | $11,697,110.00July 3, 2024

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $11,697,110.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00014 | $641,630.00December 20, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $641,630.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00013 | $0.00October 20, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00012 | $0.00July 11, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00011 | $0.00January 10, 2023

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00010 | $0.00October 25, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00009 | $12,498,467.00September 28, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $12,498,467.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00008 | $-12,498,467.00September 21, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $-12,498,467.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00007 | $0.00February 11, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00006 | $12,900,000.00January 14, 2022

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $12,900,000.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #P00005 | $0.00October 27, 2021

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00004 | $0.00May 27, 2021

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00003 | $0.00November 3, 2020

Immediate Office of the Secretary, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00002 | $0.00January 31, 2020

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $0.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

This payment could indicate a change to the existing contract.

Transaction #P00001 | $2,476,034.00May 19, 2019

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $2,476,034.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.

Transaction #0 | $15,658,035.00July 12, 2018

Office of Assistant Secretary for Preparedness and Response, a sub agency of Department of Health and Human Services, issued a payment of $15,658,035.00 to SPERO THERAPEUTICS, INC.. The payment included a Subsidy Cost of $0.00.